Klinefelter’s syndrome and XXY are not “Intersex”

Klinefelter’s syndrome and XXY are not Intersex

Response to “intersex is NOT a disease” blog by The *F* Word 

I see you’re referring to those brain cells nuclei images, I’ve seen those before in a series of videos by Veronica Drantz PhD called “Myth & Science of Sexuality” that you can find on YouTube. Dr Drantz supports the notion of male and female and transsexual and homosexual and heterosexual brain.The argument against hers is that the study she references has never been replicated, even though others have tried, many times. It may be that there are insufficient Transsexual brains to study, or it may be that cellular structure alters as the owners of them perform different exercises.  Such as we all know that if we learn to type well, without need to look at the keyboard, the cellular structure of the brain cells that control that act become larger. In me, my brain cells in that area are definitely not well developed.  But our actions determine how well our brains cope with those actions. There may be differences in the various brains because of the way the brain is used, not our actions being dictated by our brain chemistry?

However; to argue that intersex is not a disease cannot be taken seriously.  All the people I know who claim intersex as an identity do so because they have some kind of medical issue that affects their sexual development, either primary or secondary.  I see it as ‘burying their heads in the sand‘ to say their medical issues that lead them to their identity are not diseases, they clearly are diseases.

How is Klinefelter’s syndrome, (and syndrome means “a collection of symptoms indicative of disease“), not the disease that leads them to their identity if they choose to say Klinefelter’s syndrome is an intersex condition?   I argue strenuously that Klinefelter’s syndrome is by no means intersex as it only manifests after the onset of puberty in males!  How can it possibly be that these men, who have always regarded themselves as male prior to their Klinefelter’s diagnosis, suddenly become ‘intersex’ after their diagnosis, when they never made any comments prior to their diagnosis that they didn’t really feel male?  It is always the case that this ‘change of sex’ declaration comes about post diagnosis. In my view the only way an XXY man treated for Klinefelter’s syndrome can claim he’s intersex is to assert that he’s a natural Transsexual, as he chooses his intersex identity as a result of a disease he’s treated for. Therefore intersex is indeed a disease in him.

In the blog “intersex is NOT a disease” the author uses in part the karyotype  most often associated with Klinefelter’s syndrome as a description of an intersex condition.  I regard that as somewhat an erroneous application since everybody on the planet with more than 1 X chromosome only has 1 X active.  It literally does not matter how many X’s are present only 1 is actually working.  All biological women have at least 2  X chromosomes, which are inactivated randomly, meaning the chromosome is probably from the mother and father active in a 50/50 split.  It appears men with Klinefelter’s syndrome, who often have an XXY karyotype, have non random inactivation of their X chromosomes, which may well be the cause of their wide ranging difficulties?

There is also the region on the X chromosome called the “pseudo-autosomal region” (PAR) that is active, for all people with more than 1 X chromosome, all biological women, and XXY (and variant) men. The active genes in the PAR have to date nothing to do with the development of sex in XXY males, but the influence of the non random activated genes probably do account for the difficulties XXY males experience, and the more X’s present the greater the range and degree of difficulty.  The additional X is by no means irrelevant  or “meaningless” as at least one commentator has stated as argument against my assertion that XXY is not an intersex condition either.  The additional X has dramatic, chronic medical and psychological affects on us.  It can hardly be described as “natural.”

This is just a disease I know about, as I’m treated for it, and have been for 36 years.  It is absolutely true that in high school I learned that males have XY sex chromosomes and females have XX sex chromosomes, and of course that means something to me as I have always seen myself as male, just like every other XXY man saw himself as male.  But most people do not go on to higher education and do not learn about X chromosomes, or any chromosomes and autosomes. What they learned in high school was good enough for their chosen career, which in all likelihood had nothing to do with biology or science in any way.  Then they get diagnosed with Klinefelter’s syndrome and discover their karyoptype to be XXY and they’re suddenly thrown into a state of total confusion as it had never entered their head that men can also have XX, and XXY and XXYY and XXXY and all sorts of other variations and still be male.

When we’re all born our sex is determined by our physical appearance. XXY babies with male genitals are said to be boys.  As these babies grow they develop into male children and from there teenagers to men.  After the onset of puberty these  boys seem to always develop Klinefelter’s syndrome, even though there are examples of XXY boys who never develop the syndrome.  The most common characteristic of Klinefelter’s syndrome is infertility caused by Seminiferous Tubule Dysgenesis, or malformation of the seminiferous tubules, where sperm develop and grow.  Owning to that malformation, or disease of the testes, the testes themselves fail to grow to normal size. This is caused by the malformed seminiferous tubules retarding the growth of the leydig cells, the cells that produce testosterone.  Seminiferous Tubule Dysgenesis is a slow developing disease that CAN have an effect prenatally, and CAN have an effect in childhood, but has accelerated and devastating effects in puberty. With insufficient testosterone production  after the onset of puberty, gynaecomastia can develop, along with other  secondary sex characteristics normally associated with females, especially hair growth and fat development.  Any man with low testosterone can develop similar symptoms, but the reason XXY’s develop them so early is because of the degeneration of the testes at a very young age.

How are men treated for Klinefelter’s syndrome and claiming to be intersex not burying their heads in the sand?  It is the standard mantra of intersex support organisations to maintain that ‘intersex’ is a natural variation of human.  In my opinion natural variations of human can all breed, without assistance from the medical profession.  Of the men who are infertile who do not have Klinefelter’s syndrome, would they say they are a “natural variation” of human?  I don’t think so, I don’t think they’d say the disease that makes them infertile is supposed to be. I think men with Klinefelter’s syndrome pretend to be ‘intersex’ to cover their disappointment of being infertile, as in their eyes they can’t be ‘real men’ and be infertile.

Intersex is indicative of DISEASE.  Every person with an intersex identity has a pre-existing medical condition that can only be described as a DISEASE that brings about their identity.

9 thoughts on “Klinefelter’s syndrome and XXY are not “Intersex”

  1. We’ve hashed this out before, for the most part, and as stated previously I stand by my description as a medical summation. Only as that. I am well aware that the medical community is pretty screwed up when it comes to anything that does not fit the exact dichotomy of how they define sex. I think adding the subtype to the DSM is the icing on the cake in that particular regard.

    That being said, you stated something above that has quite peaked my interest.

    “Of the men who are infertile who do not have Klinefelter’s syndrome, would they say they are a “natural variation” of human? I don’t think so, I don’t think they’d say the disease that makes them infertile is supposed to be. I think men with Klinefelter’s syndrome pretend to be ‘intersex’ to cover their disappointment of being infertile, as in their eyes they can’t be ‘real men’ and be infertile.”

    This is a fantastic point, as women who are infertile for a great many reasons would NOT be considered intersex, yet the medical community insists in Klinefelter’s because of the infertility. I hate to bring this into it (ok, really I don’t. I think it’s a fabulous argument) but I think a great deal of this steps into the sphere of Masculinity Theory and what constitutes being ‘man enough’. This is more obvious in the reassignment of male infants into females, but more subtle with ‘non-clinical’ penile variations and chromosomal differences.


    • “yet the medical community insists in Klinefelter’s because of the infertility.”

      No, not the medical profession, certain XXY men who have exaggerated their condition to make out they’re intersex when they’re not.

      Why would a gay man go to a fertility clinic?
      David Iris Cameron Strachan. XXY

      How can deep vein thrombosis be caused by the procedure to insert testosterone pellets?
      Michael Noble. XXY

      All men on the planet have vestigial female reproductive organs, what so special about an XXY man having the same?
      Chris Somers. XXY


    • I don’t know that the medical profession do describe Klinefelter’s syndrome as Intersex, I know a couple of PhD’s do, Milton Diamond and Veronica Drantz, but my Endocrinologist, John W Delahunt doesn’t and the most recent Geneticist I saw, Rachel Stapleton, doesn’t.


      • Unfortunately, Diamond is a leader. Honestly, I hear the man is quite the quack, but that aside, he is too singularly focused on the biology and doesn’t give enough to social (as opposed to his arch nemesis).


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