XXY Boys should not be referred to as having Klinefelter’s syndrome

For parents out there, your children are children, this fact seems to be lost on many parents, thinking of a related matter I read a couple of days ago. I read of a mother who described her sons penis as a ‘doodle.’ I think children can get their minds and tongue around ‘penis’ more easily than ‘doodle.’ Maybe the mother does’t refer to her sons penis as a ‘doodle’ to him, maybe she was just nervous about mentioning the correct word where she was? People confident to talk about sex have no problem referring to sex organs of both sexes by their correct name, wherever they are.

Children are learning, and I know you all know that, and their first teachers are their parents, I know you all know that too. So if your son is prenatally diagnosed XXY and you decide to keep him, not kill him, I think it would be an excellent idea to learn up on genetics. Not just go along with whatever the prevailing attitude is. Actually think about it, with an analytical, mature, mind.

Go to my previous post if you want links, you can find out all you need to know there when it comes to what Klinefelter’s syndrome is, and how it got it’s name.

Bearing in mind that Klinefelter’s syndrome is the SYMPTOMS of a DISEASE, not a DISEASE in itself. So when are you parents likely to notice your XXY son is developing the beginnings of Klinefelter’s syndrome?

According to common knowledge Klinefelter’s syndrome is seen in very young boys, even babies, and there is nothing the parent can do about it. There’s a nice defeatist attitude, saves having to think about what you’re doing and and why. You’re just observers of your sons predictable life, as you’ve read about other XXY boys who appear the same. That they have 44 unique autosomes and 3 unique sex chromosomes means absolutely nothing to you. Like when you walk down the street and see other men and women you think to yourselves how all just like YOU they are!

The additional X is mostly inactivated. It’s mostly inactivated in everybody with more than 1 X chromosome, that’s all you XX mothers out there too. You can’t resign from the study of genetics just because you’re a mother. So if we look at XXX females, what SYMPTOMS of DISEASE are they named after? It must have slipped my mind, I am XXY after all and I do have a poor short term memory. Maybe I can blame that extra X? Or Klinefelter’s syndrome – the symptoms of a disease? Or my parents for me having a poor short term memory?

Getting back to XXX females, it turns out they do have noticeable educational difficulty, fancy that! They seem to have growth issues too, being slightly taller than average females, in childhood. At puberty they’re fertile, they don’t have interference in their cells preventing the development of complete puberty, and interference of their ovaries to release eggs. They don’t develop soon after the onset of puberty hypergonadtropic hypogonadism or hypogonadtropic hypogonadism. They don’t have any kind of hypogonadism. I think it’s proven, the additional X can have an effect on education and growth regardless of the sex of the person with the additional X.

So those growth issues you parents see in your XXY sons before puberty have nothing to do with Klinefelter’s syndrome, and everything to do with the fact that there is an additional X, but not in every XXY boy. In fact if you decided you could find all XXY boys by karyotyping all tall boys, you’d miss most XXY boys. Most boys who are taller than average have normal sex chromosomes. But by karyotyping ALL boys you’d find ALL XXY and XYY boys, and ALL XX boys, and ALL XXXY boys, and ALL XXXXY boys, and every other variation there is.

So why is it then that some XXY boys are more affected than others? That might have something to do with their parents? For some reason every time I chat with parents of XXY boys they all seem to assume they’re the ‘bees knees’ of parents. How can that be when they have usually never trained to be parents before they were parents? Like most parents who discover they have a child who’s different, they have to learn how to care for that child. I don’t read how the parents of these XXY boys took themselves off to parenting classes after the diagnosis. They always seem to want to be involved in genetic counselling for themselves, and be involved with support groups to compare notes with other parents, and console themselves that they’ve done nothing wrong, and never could.

Curiously Dr Johannes Nielsen (deceased) in Denmark found that of all the XXY boys who did poorly in school, who had behaviour and educational difficulty, and ‘brushes with the law’, all came from poor parenting homes. Other XXY boys who experienced educational difficulty, and emotional disturbance, were assisted by sensible parents, and their children did not end up ‘before the courts’ as they say. Parents do have a lot to do with the way in which their XXY boys learn and communicate, and their progression to adulthood.

Did I mention the 44 unique autosomes and 3 unique sex chromosomes? Oh yes I did. They all came from their parents, the genetic providers. Are the genetic providers related to all the other genetic providers of all the other XXY boys on the planet? Are all XXY males the offspring of the same family of incestuous genetic providers? I would find that somewhat hard to believe, (makes great science fiction though.) So we all have different autosomes and sex chromosomes that come from different parents, so the possibility of other genetic conditions existing in an XXY boy, that are undiscovered, is just as good as anybody else having an undiscovered genetic anomaly, or maybe even better, since they all do have an additional X chromosome. Genetics is the only area where parents can be freed from responsibility, since XXY is a random event, that cannot be predicted.

The way in which genes work is that they are said to ‘express’ like the expression of a opinion. That expression has an effect somewhere else. So since all our genes are not exactly the same as any other person on the planet, it is conceivable that genes expressing to cause good memory, do not have the intended expression and the signal is interrupted by failing genes, or non existent genes. Just because we have the same shape and number of autosomes and chromosomes does not mean the same genes on that additional X are expressing in all of us, to the same degree. It could be that the most severely affected XXY boys have more genes that escape inactivation on the additional X than most XXY boys?

One way to further settle the matter is to look at a population of persons who have no sex hormone in childhood, do they have poor short term memory? Actually no, not as a group. Maybe there are individuals with Kallmann syndrome with poor short term memory, but it is not a feature of their syndrome, that they are born with, they are hypogonadal in the womb and at birth.

It seems the only time these people have difficulty is when they fail to enter puberty properly. The initial changes of puberty do start, they just fail to continue as they have hypogonadtropic hypogonadism, where the gonadtropins are not produced to tell their gonads to start working.

So if hypogonadism is the cause of all the difficulty in XXY boys before puberty’s onset, why is hypogonadism not the cause of difficulty in childhood for Kallmann syndrome people?

Well I’m convinced:

“Nobody was ever born with Klinefelter’s syndrome. XXY pre pubertal boys cannot have Klinefelter’s syndrome. Klinefelter’s syndrome is the post onset of puberty symptoms of disease XXY men and, XXY teenage boys can develop.”

XXY boys should not be referred to as having Klinefelter’s syndrome.