Every time I read his Crap…..

This image shows 2 boys now known to be XXY. One is me. Do the images indicate wide variability of effect of the additional X in childhood?

I think they do.

6 Years App

I don’t know why I bother…. I got the PDF file, I must have got it from somewhere, must be out there? Here’s the title

Representations of Klinefelter Syndrome

Do your own search.

Page 4:

“It must be strongly emphasised that, since its discovery by Klinefelter, surprisingly very little research has been undertaken into the condition: especially the effect the extra X chromosome has on XXY individuals.”

Utter fucking rubbish! Try PubMed choose ‘Sex Chromosome Aneuploidy XXY Klinefelter’s syndrome’ for your search criteria, and read!

Results: 1 to 20 of 266

How about ‘XXY’ alone?

Results: 1 to 20 of 1370

Or Sex Chromosome Aneuploidy?

Results: 1 to 20 of 4611

Depending on what you want will determine what you find.

XXY has only been known about since 1959. Let the researchers do their job before you condemn the entire medical profession Mr Noble.

How about your next statement of pure ignorance:

Page 6

“The medical discourse commonly refers to testosterone therapy as ‘Hormone Replacement Therapy’ (HRT), which suggests the endocrinologist is merely replacing or topping up levels that have declined for unexplained reasons.”

Unexplained reasons? For someone who’s supposedly educated one wonders from where you gained this so-called ‘education?’

From 1958, my favourite report on Seminiferous Tubule Dysgenesis the symptoms of which are called Klinefelter’s syndrome.

http://jcem.endojournals.org/content/18/12/1359

But there was one other completely ignorant statement that caught my attention, this one:

pp 14-15

“The logic of this argument suggests that, as there are no visible manifestations of the extra X chromosome, and many XXY individuals never develop the endocrinal characteristics associated with Klinefelter Syndrome, XXY therefore is not Klinefelter Syndrome.♠ Such a separation of the two conditions seems reasonable and is historically supported by H. Klinefelter’s initial diagnosis of the Syndrome as an endocrinal condition. The NZKA claims Klinefelter Syndrome is simply a form of hypogonadism, which ‘can be found in anyone who has an under supply of sex hormone .”

Yes Michael, Klinefelter’s syndrome is ‘hypogonadtropic hypogonadism’ whether you like it or not.

Separating childhood effect of the additional X genes, and the symptoms of disease that may occur does not imply anything. It’s just sensible and logical.

Your mind works in mysterious ways.

However new theory suggests you may well have gained your unusual mind because of low testosterone specifically in puberty?

Your brain may not have been receiving sufficient testosterone to reason & feel emotion?

You may have a hormonal reason to develop, or make worse, psychiatric diseases such as:

Schizophrenia?
Depression?
Attention Deficit Hyperactivity Disorder?
Conduct Disorder?

This is all just theory, not an absolute.

Unless the findings are concrete, like “77% of the boys studied had a normally sized penis by the end of puberty” Ratcliffe 1999, all the researchers I read use the word “may” repeatedly, and you often appear to interpret ‘may’ as ‘will!’

The additional X genes, since most of the additional X is inactivated, may cause some XXY boys to develop excessive bone growth in childhood?

This is also a symptom of Seminiferous Tubule Dysgenesis – aka hypogonadtropic hypogonadism – aka “Klinefelter’s syndrome” which earlier researchers may have been confused over?

New research proves additional X genetic material does cause extra bone growth in all children both males and females. However what is not certain is whether it’s the existence of that additional X material, or the concentration of specific to parent of origin genetic material, or skewed X inactivation?

We’re only talking about a few genes, not entire chromosomes.

I don’t know if XXX females have random or skewed X inactivation, I suspect they have skewed X inactivation, just like XXY males do, including YOU!

Anyway your 2010 update seems to be woefully inadequate, for your ‘unpublished’ document.