X Inactivation

Fun stuff eh!

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Everybody knows about genetics. Everybody knows males have XY sex chromosomes, and everybody knows females have XX sex chromosomes. Well everybody who studied basic biology in high school knows this anyway.

Did you know that “X inactivation has been studied for over half a century?” You should know that if you bothered to read this link, I so generously provided, in my last post. I see Australians are taking a keen interest in my blog at the moment! Geez I wonder why?

My interest in genetics goes way beyond basic high school biology, probably because of this:

cropped-ktype.jpg

However I’ve been interested in genetics since I was 14, but I wasn’t diagnosed until I was 16, and officially treated since I was 17. I suppose investigations into my suitability to be treated counts as ‘treatment’ in some peoples eyes, but not mine.

All the people I’ve ever seen who claim intersex on the basis of an inactivated X chromosome, that they had no idea was inactivated, because of their limited knowledge, raises a whole heap of questions. Imagine, if you will, that some people literally change their sex on the basis of incomplete information! How they feel about their sex after they know they’re XXY appears to change. Then they have to make up stories as to why they didn’t express such feelings BEFORE they knew. Absolutely ALL of them do it. This is the power of the human mind at work, not the power of genetics. Because of their limited knowledge they become intersex, from male, then convince themselves sometimes that their gross misunderstanding literally changes their sex. Absolutely amazing stuff!

Did you know if there wasn’t X inactivation the entire human species wouldn’t be here? It’s all about gene expressions. There is a such a thing as a ‘lethal dose.’ So if we all had all that additional X genetic material floating around inside our cells, just buggering up the system, all X chromatin positive females, and all XXY males would be severely mentally retarded at the very least. Most likely the overdose of X genes would be lethal!

Curiously I read one time that 50% of XXY pregnancies end in spontaneous abortion. I wonder if there’s a link? I wonder if it is possible for the X inactivation process to not work at all, and the bundle of cells that was a the zygote, the developed into an embryo, just couldn’t handle all that additional X genetic material and self destructed? For those XXY men out there who still think they have an entire additional X functioning in all their cells, this can be the only possible result if it were true.

Many of these men write their karyotype as XXy. They imply they do have 2 complete X’s functioning by that method. They also imply all X chromatin positive females also have 2 complete X’s functioning. If they were going to be true to gene expression they ought to type xXY as their little spoken of Y chromosome has a great deal more genetic material fully functioning, than the few genes that are known to function, and are theorised to function on the inactivated X. So really we shouldn’t say we XXY males have an ‘additional X’ we should say we have an ‘inactivated X.’ From my way of thinking that would be true to genetic reality, and from their way of thinking that would make them more like females! 🙂

The advancement in genetics, and published results from longitudinal studies, puts to rest the theories of earlier researchers into Klinefelter’s syndrome regarding what sex we are. In Mr Noble’s ‘unpublished’ (and really should remain so) document he explores comments by early researchers that XXY males are more like females with an additional Y. This theory is based on the physical characteristics of the symptoms of disease. Symptoms of disease most XXY males do not develop, and certainly do not have prior to puberty. XXY boys prior to puberty do not look like girls. If they did they’d be dead easy to find at puberty as all those originally thought of as girl children would suddenly grow male genitalia and have balls to palpate!

Mr Noble also explores an idea that Klinefelter’s syndrome does exist prior to puberty by quoting some unknown to myself researcher who postulates that “if hypogonadism were present in prepubertal XXY boys….” but set it to rest now, there is no hypogonadism. XXY boys produce testosterone from their testes, like XY boys do.

The extra height sometimes associated with men with Klinefelter’s syndrome, due to late epiphyseal closure, is also noted in XXY boys, and XXX girls, and XYY boys. By some means or other, not fully understood, additional X genetic material, and additional Y genetic material, causes extra leg growth in both males and females. BUT males and females who have Kallmann syndrome do not have additional X or Y genetic material, and do not have a feature of their disease increased linear growth in childhood, and they are hypogonadal in childhood, even in the womb!

Title

XXY Conclusions

47XXX Growth

47XYY Growth

Is No Body Shameful?

Of course there are ‘shameful’ bodies!

Anybody who insists their chromosomes dictate their sex is deluded. Do you know people with XY sex chromosomes can have female everything external, and do you know that people with XX sex chromosomes can have male everything external?

Actually the XX male persons are said to have Klinefelter’s syndrome as they have seminiferous tubule dysgenesis, and to have that disease they must have testes of course! So they’re obviously male, always were.

So where am I going…..? I get really pissed off with some of these intersex types, like most of them are so fucking lucky, they got diagnosed at birth! Then they bitch and moan about the medical care they received as if it were a bad thing!

Do you know there’s a theory out there in ‘research land’ (that’s a mythical world where people in white coats a hang out and read reams of paper literature) that says that XXY males suffer greatly from insufficient testosterone during puberty, that they’d be better off if they had no puberty at all, like males with Kallmann syndrome, effectively!

True, males with Kallmann syndrome don’t suffer they types of difficulty XXY males suffer, and it is theorised this is because males with Kallmann syndrome their testes fail to produce testosterone, thus saving their brain from psychiatric illness. XXY males on the other hand experience puberty normally, then their testosterone level markedly drops off, sometime after the onset of puberty. Nobody knows exactly when and nobody seems interested in finding out exactly when! They’re males after all, who gives a shit about males sexual & mental health?

Of course there are always exceptions to the rule.

Remember also, psychiatric illness has NOTHING to do with learning ability.

But these intersex types, their only problems are man made! Yeah they discover they’d been lied to all their lives, (that’s something for transsexual people to remember, when you lie about a matter your entire life the people you lie to get hurt!) And intersex types, they feel betrayed, depressed, anxious, angry, that can lead to psychological problems. But they’re so lucky that they had doctors who gave a shit about them, who made sure they had a NORMAL puberty, the very thing all XXY guys don’t have!

Transsexual people usually have a NORMAL puberty too! Be it the wrong sex but hey, normal all the same.

Now you’ve got to read the fine print in “The Interface Project” on YouTube, these intersex types have an introduction video, and what the people say is compelling, but the text in the video is off putting.

I know for a fact they all believe XXY guys are intersex, not that it’s any of their business of course! They wholeheartedly believe all XXY guys have Klinefelter’s syndrome, these intersex types are really good at spouting medical dogma, when it doesn’t apply to them! They want to force XXY boys to develop psychiatric disorders, because they’re receiving information from crackpots who lie about even how they a were diagnosed, about their medical care, the structure of their internal organs, anything to fit into the intersex group they will lie about.

So why do some of the XXY guys want to fit into a group they don’t belong in? Could it be that they’re all homosexual and the support groups of the 1990’s didn’t cater for them, and they had nowhere else to go? Of course, I think it’s pretty well proven sex chromosome numbers do not dictate sexuality, but these homosexual XXY guys really want it to be true for them! If XXY causes homosexuality then all XXY males MUST be homosexual, and we know for a fact that’s not true!

Should an XY female have her internal, non sperm making, testes removed, and if they are removed is that sterilisation? I do know of AIS, 46XY females who were not diagnosed until adulthood, and none have ever elected to keep their non sperm producing, testosterone producing gonads. They’re not being sterilised, they’re being assisted. So I don’t think AIS females diagnosed at birth, or in childhood are being sterilised either, they’re being assisted. They’re given what most XXY guys don’t have a NORMAL life! Now if Eden Atwood wants to have the effects of her testes back, all she need do is have testosterone supplementation, if she wants?

So getting back to XXY boys, should they be forced to have testosterone therapy? I don’t think they are forced to. It’s only the crackpot XXY guys who pretend they’re intersex who claim they are! Oh no I do know of 1 XXY man who was forced to have testosterone therapy when he was a teen by his parents, and as soon as he hit 18 he stopped the therapy, at grave risk to his health! That is exactly what doctors want to avoid, which is exactly why they INSIST it’s the XXY boy HIMSELF who decides if he wants hormone therapy. Of course stupid parents will do stupid things regardless of the best advice!

Of XXY boys in puberty this is what I have NEVER found, they don’t want erections, they don’t want sex, they don’t want to masturbate, they don’t want to ejaculate. When they realise they need testosterone to do all those things, they agree to hormone therapy. It’s only these pretend intersex crackpot XXY adults who want to claim their hormone therapy was a disaster. One famous XXY idiot maintains he was better off being sexually incapable, and wished he’d never started testosterone therapy, but only did so because he was not informed of all the consequences of that therapy. So who as an adult needs to be informed as to the effects of testosterone when as an adult he sought out therapy? Oh he also claims he might die if he stops the therapy he was ‘forced’ to take, which is utter nonsense!

Who the hell’s he trying to kid here? This sort of crap might be really well received by the intersex types, the true intersexers I mean, but it just doesn’t wash with normal bodied people. Normally testosterone is produced by the testes in males at about 50-70mgs per day, when the men are resting. Many men seem to think they wake after resting with an erection as they need to piss, but it’s pure co-incidence. Just ask yourself men, during the day, and you’re awake when you need to pee do you have an erection? Well I’m a man and I don’t, but I do have morning erections, because the testosterone I have is not being used for all the other things it’s needed for and goes straight to my penis, just the same as any other man, when he’s resting.

So what happens if they don’t produce that 50-70mgs per day? Do you really think they still wake up erect? Do they have sexually explicit dreams? Do they think about sex at all? So if an XXY man doesn’t want these terribly manly things what does he have to do? Cut his balls off! Not on your life he doesn’t, all he has to do is stop having the testosterone therapy. Making that personal choice might be quite difficult for some XXY men, when it all goes wrong who can they blame but themselves?

Now if these intersex types want to influence the medical profession to not treat them with hormones, of course they can feel free, they’re adults after all and it’s their health that’s at stake, nobody can be hurt but them. But for them to advocate that NOBODY with a DSD should be treated with hormones because of their not necessarily true accounts, is just plain nonsense. How can they possibly expect to have any influence in the health care of persons not related to them, not even in their circle of friends, based on their dubious accounts?

XXY boys deserve to be diagnosed early, before the onset of puberty, and ought to have the right to go through puberty just like any other males on the planet, and not be forced to develop possible psychiatric illness just because these intersex types have not got a clue what they’re talking about. If they want my continued support they’re going to have to tone down the text in their video. They’re going to have to accept that XXY boys forced to develop Klinefelter’s syndrome will not have a good opinion of their own most ugly body, as it’s counter intuitive for healthy males to look like that! Even their crackpot XXY colleagues don’t have that fat ugly body, BECAUSE they have testosterone therapy!

In my opinion.